عنوان مقاله [English]
Abstract: In order to better understand and improve the treatment of cancer, the study of the structural properties and mechanical properties of healthy cell tissues is of great importance. Therefore, the process of Nano manipulation of cancerous and healthy tissues using atomic force microscopy leads to the recognition of this disease. In this study, the critical force and time of gastric cancer tissue in the manipulation process have been evaluated by considering frictional forces with different models. In the general process of manipulation, a critical force occurs when overcoming resistive forces such as friction, and the high force causes damage to cancerous tissues. Coulomb, LuGre and HK friction models have been used in this research. By analyzing the topographic images obtained by atomic force microscopy, the geometry of gastric cancer tissue is assumed to be spherical. The simulations are performed by different friction models. Graphs of all forces are plotted in 2D manipulation, and the resultant force diagram is used for comparison. After fixing the amount of force in different friction models, the amount of force and critical time are considered. The lowest force and critical time for gastric cancer tissue were also recorded for the LuGre friction model with 0.51 nN and 64 ms.