مروری جامع بر فعالیت زیست سازگاری (M=Mn, Ca, Zn) MFe2O4به عنوان نانوحامل دارو سرطان سینه سنتز شده به روش عملیات گرمایی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 مرکز تحقیقات نانوبیوتکنولوژی، دانشگاه علوم پزشکی بقیه الله (عج)، تهران، ایران

2 گروه فیزیک، دانشکده علوم پایه، ، دانشگاه ملی ملایر، ملایر، ایران

3 دانشگاه ملایر،دانشکده علوم پایه،گروه فیزیک

چکیده

در این پژوهش، نانوذرات فریت منگنز (Mn)، فریت کلسیم (Ca) و فریت روی (Zn) با روش عملیات گرمایی سنتز شدند. مقدار  بارگذاری و رهایش کورکومین (CUR) از نانوحامل­هایMn ،Ca  و  Znدر pH­های متفاوت بررسی شد. درصد بارگذاری دارو در نانوحامل‌های Mn نسبت به Ca و Zn بیشتر بوده که نتیجه خنثی بودن فریت منگنز در محیط بارگذاری است. برهمکنش قوی π-π بین CUR و نانوحامل‌های فریت منگنز باعث افزایش درصد بارگذاری دارو می­شود. با تغییر pH از 4/7 به 5/5، رهایش کورکومین از نانوحامل­هایMn ،Ca  و  Znبه ترتیب از 41، 7/24 و44 درصد به 92، 7/58 و 53 درصد افزایش یافت. زیست سازگاری نانوحامل‌هایMn ،Ca  و  Znبا استفاده از روش MTT، آزمایش همولیز و آزمون دوز کشنده تعیین شد. بررسی‌ها نشان داد که علی‌رغم اینکه در حضور نانوحامل‌های Zn، درصد بالایی از سلول­های سرطانی MCF-7 تخریب می‌شوند اما این نانو حامل­ها بر سلول‌های نرمال HEK-293 تأثیر مخربی دارند.

کلیدواژه‌ها


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