نانومقیاس

نانومقیاس

پیشرفت‌های اخیر در کاربرد چاپ زیستی سه‌بعدی در ترمیم زخم: مقاله مروری

نوع مقاله : مقاله پژوهشی

نویسندگان
1 مرکز تحقیقات تروما، دانشگاه علوم پزشکی آجا، تهران، ایران
2 دپارتمان نانوتکنولوژی پزشکی، دانشکده علوم نوین پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران
چکیده
پوست به عنوان بزرگترین ارگان بدن همواره در معرض آسیب‌های خارجی ناشی از منابع مختلف از جمله شرایط پزشکی مانند دیابت، چاقی و سوختگی است. امروزه مدیریت درمان آسیب‌های پوستی و پیشرفت در مدیریت ترمیم زخم از اهداف اصلی پزشکی بازساختی محسوب میشود. بنابراین نیاز به سازه ای مهندسی شده برای مدیریت زخم به گونه ای که بتواند مراحل بازسازی را در مدت زمان کمتر انجام دهد امری اجتناب ناپذیراست. در سال‌های اخیر، ساخت جایگزین‌های بهبودیافته برای پوست یکی از چالش‌برانگیزترین مسائل در مهندسی بافت پوست بوده است. اخیراً، مهندسی بافت با بهره‌گیری از روش‌های نوآورانه چاپ زیستی سه‌بعدی، تحولی در درمان آسیب‌های پوستی ایجاد کرده است. چاپ زیستی سه‌بعدی با استفاده از طیف گسترده‌ای از بیومتریال‌ها و سلول‌ها، ساختارهایی را تولید می‌کند که شباهت زیادی به بافت‌های طبیعی دارند و چالش‌های مربوط به درمان‌های مکرر را برطرف می‌سازند.
در این مقاله مروری، ابتدا به بررسی چندین نوع چاپ زیستی سه‌بعدی، از جمله چاپ زیستی قطره‌ای، چاپ زیستی اکستروژن و چاپ زیستی استریولیتوگرافی می‌پردازیم. سپس، نقش چاپ زیستی سه‌بعدی در تولید جایگزین‌های پوستی با خواص ضدباکتریایی و آنتی‌اکسیدانی را مورد بحث قرار خواهیم داد. در نهایت، کاربرد این فناوری در ساخت ابزارهای عروقی برای بازسازی پوست را بررسی خواهیم کرد.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Recent advances in the application of 3d bioprinting for skin injuries and wound healing: A review

نویسندگان English

Amir Nezami Asl 1
Negar Karimi Hajishoreh 1
Abolfazl Akbarzadeh 2
1 Trauma research center, Aja University of Medical Sciences, Tehran, Iran
2 Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده English

Skin injuries and advancements in wound healing are major objectives in biomedical engineering worldwide. In recent years, fabricating improved skin substitutes has been one of the most challenging issues in skin tissue engineering. A critical stage in the wound healing process is neovascularization. However, from a medical perspective, most standard approaches have failed to address this effectively. Recently, tissue engineering has begun utilizing innovative 3D bioprinting methods to revolutionize the treatment of skin injuries. 3D bioprinting addresses the challenges of repetitive therapy by employing a wide range of biomaterials and cells to fabricate structures that closely resemble native tissues. In this review, we will begin by highlighting several types of 3D bioprinting, including droplet-based bioprinting, extrusion bioprinting, and stereolithography bioprinting. Next, we will discuss the role of 3D bioprinting in producing skin substitutes with antibacterial and antioxidant properties. Finally, we will explore the use of 3D bioprinting technology to fabricate vascular tools for skin regeneration.

کلیدواژه‌ها English

Skin Damage
3D Bioprinting
Neovascularization
[1] Naniz MA, Askari M, Zolfagharian A, Naniz MA, Bodaghi M. “4D printing: a cutting-edge platform for biomedical applications.” Biomedical Materials. 2022;17(6):062001. https://doi.org/10.1088/1748-605X/ac8e42
[2] Derakhshanfar S, Mbeleck R, Xu K, Zhang X, Zhong W, Xing M. “3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances.” Bioactive Materials. 2018;3(2):144-56. https://doi.org/10.1016/j.bioactmat.2017.11.008
[3] Gu Z, Fu J, Lin H, He Y. “Development of 3D bioprinting: From printing methods to biomedical applications.” Asian Journal of Pharmaceutical Sciences. 2020;15(5):529-57. https://doi.org/10.1016/j.ajps.2019.11.003
[4] Peng W, Unutmaz D, Ozbolat IT. “Bioprinting towards physiologically relevant tissue models for pharmaceutics.” Trends in Biotechnology. 2016;34(9):722-32. https://doi.org/10.1016/j.tibtech.2016.05.013
[5] Knowlton S, Yenilmez B, Anand S, Tasoglu S. “Photocrosslinking-based bioprinting: Examining crosslinking schemes.” Bioprinting. 2017;5:10-8. https://doi.org/10.1016/j.bprint.2017.03.001
[6] Aljohani W, Ullah MW, Zhang X, Yang G. “Bioprinting and its applications in tissue engineering and regenerative medicine.” International Journal of Biological Macromolecules. 2018;107:261-75. https://doi.org/10.1016/j.ijbiomac.2017.08.171
[7] Vijayavenkataraman S, Yan W-C, Lu W-F, Wang C-H, Fuh JYH. “3D bioprinting of tissues and organs for regenerative medicine.” Advanced Drug Delivery Reviews. 2018;132:296-332. https://doi.org/10.1016/j.addr.2018.07.004
[8] Topuz M, Dikici B, Gavgali M, Yilmazer H. “A review on the hydrogels used in 3D Bio-printing.” International Journal of 3D Printing Technologies and Digital Industry. 2018;2(2):68-75.
[9] Gross BC, Erkal JL, Lockwood SY, Chen C, Spence DM. “Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences.” ACS Publications; 2014. https://doi.org/10.1021/ac403397r
[10] Bishop ES, Mostafa S, Pakvasa M, Luu HH, Lee MJ, Wolf JM, et al. “3D-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends.” Genes & Diseases. 2017;4(4):185-95. https://doi.org/10.1016/j.gendis.2017.10.002
[11] Yan Q, Dong H, Su J, Han J, Song B, Wei Q, Shi Y. “A review of 3D printing technology for medical applications.” Engineering. 2018;4(5):729-42. https://doi.org/10.1016/j.eng.2018.07.021
[12] Yenilmez B, Temirel M, Knowlton S, Lepowky E, Tasoglu S. “Development and characterization of a low-cost 3D bioprinter.” Bioprinting. 2019;13:e00044. https://doi.org/10.1016/j.bprint.2019.e00044
[13] Mani MP, Sadia M, Jaganathan SK, Khudzari AZ, Supriyanto E, Saidin S, et al. “A review on 3D printing in tissue engineering applications.” Journal of Polymer Engineering. 2022;42(3):243-65. https://doi.org/10.1515/polyeng-2021-0059
[14] Bit A, Suri JS, Gupta S. “3D bioprinting in tissue engineering and regenerative medicine.” Flow Dynamics and Tissue Engineering of Blood Vessels: IOP Publishing; 2020. https://doi.org/10.1088/978-0-7503-2088-7
[15] Raman R, Bashir R. “Stereolithographic 3D bioprinting for biomedical applications.” Essentials of 3D Biofabrication and Translation: Elsevier; 2015. p. 89-121. https://doi.org/10.1016/B978-0-12-800972-7.00006-2
[16] Brand I, Groß I, Li D, Zhang Y, Bräuer AU. “Pneumatic conveying printing technique for bioprinting applications.” RSC Advances. 2019;9(70):40910-6. https://doi.org/10.1039/C9RA07521F
[17] Liu J, He J, Liu J, Ma X, Chen Q, Lawrence N, et al. “Rapid 3D bioprinting of in vitro cardiac tissue models using human embryonic stem cell-derived cardiomyocytes.” Bioprinting. 2019;13:e00040. https://doi.org/10.1039/C9RA07521F
[18] Gudapati H, Dey M, Ozbolat I. “A comprehensive review on droplet-based bioprinting: Past, present and future.” Biomaterials. 2016;102:20-42. https://doi.org/10.1016/j.biomaterials.2016.06.012
[19] Daikuara LY, Chen X, Yue Z, Skropeta D, Wood FM, Fear MW, Wallace GG. “3D bioprinting constructs to facilitate skin regeneration.” Advanced Functional Materials. 2022;32(3):2105080. https://doi.org/10.1002/adfm.202105080
[20] Tabriz AG, Douroumis J, Boateng J. “3D printed scaffolds for wound healing and tissue regeneration.” Therapeutic Dressings and Wound Healing Applications. 2020:385-98. https://doi.org/10.1002/9781119433316.ch17
[21] Milojević M, Harih G, Vihar B, Vajda J, Gradišnik L, Zidarič T, et al. “Hybrid 3D printing of advanced hydrogel-based wound dressings with tailorable properties.” Pharmaceutics. 2021;13(4):564. https://doi.org/10.3390/pharmaceutics13040564
[22] Fayyazbakhsh F, Khayat MJ, Leu MC. “3D-printed gelatin-alginate hydrogel dressings for burn wound healing: A comprehensive study.” International Journal of Bioprinting. 2022;8(4). https://doi.org/10.18063/ijb.v8i4.618
[23] Nizioł M, Paleczny J, Junka A, Shavandi A, Dawiec-Liśniewska A, Podstawczyk D. “3D printing of thermoresponsive hydrogel laden with an antimicrobial agent towards wound healing applications.” Bioengineering. 2021;8(06):79. https://doi.org/10.3390/bioengineering8060079
[24] Domínguez-Robles J, Martin NK, Fong ML, Stewart SA, Irwin NJ, Rial-Hermida MI, et al. “Antioxidant PLA composites containing lignin for 3D printing applications: a potential material for healthcare applications.” Pharmaceutics. 2019;11(4):165. https://doi.org/10.3390/pharmaceutics11040165
[25] Yang Z, Ren X, Liu Y. “N-halamine modified ceria nanoparticles: antibacterial response and accelerated wound healing application via a 3D printed scaffold.” Composites Part B: Engineering. 2021;227:109390. https://doi.org/10.1016/j.compositesb.2021.109390
[26] Joshi A, Choudhury S, Gugulothu SB, Visweswariah SS, Chatterjee K. “Strategies to Promote Vascularization in 3D Printed Tissue Scaffolds: Trends and Challenges.” Biomacromolecules. 2022;23(7):2730-51. https://doi.org/10.1021/acs.biomac.2c00423
[27] Nakamura M, Kobayashi A, Takagi F, Watanabe A, Hiruma Y, Ohuchi K, et al. “Biocompatible inkjet printing technique for designed seeding of individual living cells.” Tissue Engineering. 2005;11(11-12):1658-66. https://doi.org/10.1089/ten.2005.11.1658
[28] Abaci HE, Guo Z, Coffman A, Gillette B, Lee Wh, Sia SK, Christiano AM. “Human skin constructs with spatially controlled vasculature using primary and iPSC-derived endothelial cells.” Advanced Healthcare Materials. 2016;5(14):1800-7. https://doi.org/10.1002/adhm.201500936
[29] Weng T, Zhang W, Xia Y, Wu P, Yang M, Jin R, et al. “3D bioprinting for skin tissue engineering: Current status and perspectives.” Journal of Tissue Engineering. 2021;12:20417314211028574. https://doi.org/10.1177/20417314211028574
[30] Chouhan D, Dey N, Bhardwaj N, Mandal BB. “Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances.” Biomaterials. 2019;216:119267. https://doi.org/10.1016/j.biomaterials.2019.119267
[31] Cui H, Zhu W, Nowicki M, Zhou X, Khademhosseini A, Zhang LG. “Hierarchical fabrication of engineered vascularized bone biphasic constructs via dual 3D bioprinting: integrating regional bioactive factors into architectural design.” Advanced Healthcare Materials. 2016;5(17):2174-81. https://doi.org/10.1002/adhm.201600505
[32] Hudon V, Germain L, Tremblay P-L, Auger FA, Berthod F. “Inosculation of tissue-engineered capillaries with the host’s vasculature in a reconstructed skin transplanted on mice.” 2005.
[33] Lee SB, Jeon HW, Lee YW, Lee YM, Song KW,Park MH, et al. Bio-artificial skin composed of gelatin and [1→ 3],[1→ 6]-β-glucan.
دوره 12، شماره 2
تابستان 1404
صفحه 188-198

  • تاریخ دریافت 21 اسفند 1403
  • تاریخ بازنگری 30 خرداد 1404
  • تاریخ پذیرش 15 آبان 1404