In this study, the mesostructure of SBA-16 was used as a drug carrier. The physicochemical characteristics were determined by X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and elemental analysis (EDX) to confirm the structure of SBA-16 after synthesis. The effect of effective parameters on drug loading, including pH, initial drug concentration, amount of nanocarrier, temperature and contact time was investigated using response surface method (RSM), central compound model (CCD) by design of experiment software (DOE). Drug release in three simulated body environments at 37 degrees Celsius, including neutral environment with 6.8, acidic with 4.8 and alkaline with 7.4 at times 1, 2, 3, 4, 12, 24, 48 and 72 The watch was read. The data obtained from isotherm and drug loading kinetics studies showed that the drug loading process follows the Langmuir isotherm with R2=0.9964 and the pseudo-second order kinetic model with R2=0.9992. Also, thermodynamic studies showed that drug loading on SBA-16 nanocarrier is an exothermic and spontaneous process.