گروه نانو فناوری پزشکی، دانشکده ف نآوری های نوین پزشکی، دانشگاه علوم پزشکی تهران، تهران
عنوان مقاله [English]
Size is one of the most important physical factors of nanoparticles NPs. The size of the NPs can be effective in application of particles, especially in designing of drug delivery systems. NPs size could regulate blood half life, immunogenicity and toxicity of them. So determination factors affecting the size can be very helpful in various applications. In this study the influence of various factors, including chitosan concentration, pH and reaction time as independent variables, on the self-assembled NPs were investigated. Artificial neural networks were used to study the relationship between the independent and dependent variables. The results showed that chitosan concentration is the most important factor and has a direct effect on size. pH and reaction time have slight effect on size. Increasing pH would decrease the size but increasing pH would lead to increasing size. In total for preparation of chitosan / albumin NPs in desired size, polymer concentration, pH and reaction time must be adjusted.