کاربرد نانو ذرات اکسید مس در بارگیری داروی گاباپنتین به روش‌های اپتیکی خطی و غیر‌خطی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه فیزیک دانشگاه حکیم سبزواری

2 گروه شیمی، دانشکده علوم پایه، دانشگاه حکیم سبزواری

3 گروه شیمی دانشگاه حکیم سبزواری

4 گروه شیمی دانشگاه نیشابور

چکیده

در این پژوهش ، نانوذرات مس اکسید بروش سل-ژل سنتز شده و ­ابی به روش­های پراکندگی اشعه ایکس و نور دینامیک (DLS)، میکروسکوپ گذار الکترونی و میکروسکوپ الکترونی سطحی انجام شد که تشکیل ساختارهای کریستالی با سایز ذرات 22 نانومتر را تایید می­نمود. داروی گاباپنتین با مقادیر متفاوت روی ذرات بارگیری و به روش­های اندازه­گیری نوری خطی (طیف مرئی-فرابنفش) و غیر خطی (روبش زد با دریچه باز) میزان بارگیری بررسی شد. در اندازه­گیری DLS مشاهده شد که افزایش میزان بارگیری سبب افزایش شعاع هیدرودینامیکی به خاطر تجمیع ذرات و یا ایجاد هاله دارویی اطراف ذرات می­شود که افزایش در جذب نوری را منجر می­شود. همچنین، افزایش جذب ذرات باعث افزایش جمعیت تراز بالایی (نوار رسانش) نسبت به پایینی (نوار ظرفیت) و اشباع کلوئید برای جذب نور می­شود که این ویژگی با آزمایش روبش زد با دریچه باز تایید شد. اثر فوتوآکوستیکی نانوذرات مس اکسید با لیزر آبی برای نخستین بار در این آزمایش دیده شد ولی بر خلاف نتایج دیگر آزمایش­ها این اثر نمی­­تواند معیاری برای سنجش میزان بارگیری دارو باشد. در مجموع روش­های نوری خطی و غیرخطی مانند طیف جذبی و روبش زد روش­هایی دقیق برای سنجش میزان بارگیری دارو بر نانو ذرات اکسید مس تشخیص داده شدند.

کلیدواژه‌ها


عنوان مقاله [English]

Application of copper oxide nanoparticles in loading of gabapentin drug using linear and nonlinear optical methods

نویسندگان [English]

  • Ehsan Koushki 1
  • Reza Tayebee 2
  • Fahimeh Khedmatgozar 3
  • Vahid Sokhanvaran 4
  • Amir Hossein Ehsanian 1
1 Department of physics . Hakim Sabzevari university
2 Department of chemistry, Hakim Sabzevari university
3 Department of chemistry, Hakim Sabzevari university
4 Department of chemistry, Neyshabur university
چکیده [English]

In this study, copper oxide nanoparticles were synthesized by sol-gel method and characterizations were performed using of x-ray diffraction and dynamic light scattering (DLS), electron transition microscopy (TEM) and surface electron microscopy (SEM) which confirm the formation of 22 nm crystal structures. After that, gabapentin drug was applied to the particles in different amounts and loading process was studied by some methods such as; linear optical method (visible-ultraviolet spectrum) and nonlinear optical method (open-aperture z-scan method). In DLS measurements, it was observed that increasing the loading, increases the hydrodynamic radius due to the aggregation of particles or the formation of a drug halo around the particles, which leads to an increase in the light absorption of the material. Also, increasing the particle absorption increases the population of high level (conduction band) compared to low (capacity band) and colloid became saturated for light absorption, which was confirmed by open aperture z-scan experiment. The photoacoustic effect of copper oxide nanoparticles with blue laser was seen for the first time in this experiment, but unlike the results of other experiments, this effect cannot be a criterion to measure of drug loading. In summary, linear and nonlinear optical methods such as absorption spectrum and open aperture z-scan technique have been found precise methods to measuring amount of drug loading on copper oxide nanoparticles.

کلیدواژه‌ها [English]

  • loading surface agents
  • copper oxide nanoparticles
  • z-scan method
  • photoacoustic effect
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