نوع مقاله : مقاله پژوهشی
موضوعات
عنوان مقاله English
نویسندگان English
Application of Bloch Surface Waves (BSWs) for detection of Furosemide using nanostructure Photonic crystals has been introduced in this paper. BSWs, as an electromagnetic phenomenon in periodic dielectric structures, were employed to detect various concentrations of the drug furosemide in distilled water. 24 layers' photonic crystal composed of alternating ZrO₂ and SiO₂ layers was fabricated as a dielectric sensing medium, allowing the evanescent field generated at the terminal surface to interact with furosemide molecules. To excite the BSWs, the Kretschmann-Raether configuration was used, incorporating a 635 nm red laser source and a semi-cylindrical BK7 prism. A precise volume of 20 µL of furosemide solution at concentrations of 1, 1.5, 2, and 3.5 mM was deposited onto the surface of the photonic crystal. The reflectance of TM-polarized light was recorded within the angular range of 40° to 70°. Experimental results showed that the resonance angle shifted significantly with increasing furosemide concentration, specifically, the resonance angle changed from 51.941° in pure water to 52.245° at 1 mM, 52.549° at 2 mM, and 52.853° at 3.5 mM. The system demonstrated an approximately linear sensitivity to concentration changes within this range. These results highlight the potential of BSW-based photonic crystal sensors for the detection of doping-related drugs such as furosemide in clinical and sports medicine applications.
کلیدواژهها English