Nanomeghyas

Nanomeghyas

Recent advances in the application of 3d bioprinting for skin injuries and wound healing: A review

Document Type : Original Article

Authors
Amir Nezami Asl 1
Negar Karimi Hajishoreh 1
Abolfazl Akbarzadeh 2
1 Trauma research center, Aja University of Medical Sciences, Tehran, Iran
2 Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
10.22034/ns.2025.2055667.1380
Abstract
Skin injuries and advancements in wound healing are major objectives in biomedical engineering worldwide. In recent years, fabricating improved skin substitutes has been one of the most challenging issues in skin tissue engineering. A critical stage in the wound healing process is neovascularization. However, from a medical perspective, most standard approaches have failed to address this effectively. Recently, tissue engineering has begun utilizing innovative 3D bioprinting methods to revolutionize the treatment of skin injuries. 3D bioprinting addresses the challenges of repetitive therapy by employing a wide range of biomaterials and cells to fabricate structures that closely resemble native tissues. In this review, we will begin by highlighting several types of 3D bioprinting, including droplet-based bioprinting, extrusion bioprinting, and stereolithography bioprinting. Next, we will discuss the role of 3D bioprinting in producing skin substitutes with antibacterial and antioxidant properties. Finally, we will explore the use of 3D bioprinting technology to fabricate vascular tools for skin regeneration.
Keywords
Skin Damage
3D Bioprinting
Neovascularization
Subjects

  • Receive Date 11 March 2025
  • Revise Date 20 June 2025
  • Accept Date 06 November 2025