Nanomeghyas

Nanomeghyas

Green synthesis of gold nanoparticles with beet extract and investigation of its anti-cancer properties

Document Type : Original Article

Authors
Somaye Haraty Rad 1
ziba sorinezami 2
Mansour Ghaffari Moghaddam 2
Mostafa Khajeh 3
Ashkan Keshavarzi 4
Davood Ghanbari 5
1 faculty of science- university of zabol- zabol
2 faculty of science- university of zabol- zabol-iran
3 faculty of science- university of zabol- zabol- iran
4 materials and energy research center- karaj- iran
5 Arak University of Technology
Abstract
In this study, the synthesis of gold nanoparticles and its anti-cancer properties were studied. In order to obtain gold nanoparticles with morphology, appropriate size and stability of microwave, sonochemical and green synthesis methods using HAuCl4, tri sodium citrate, PVP (polyvinylpyrrolidine), chitosan and beet extract were used. Morphology, uniform distribution and the size of nanoparticles synthesized by XRD, SEM, FT-IR, UV-Vis and TEM devices were studied. Nanoparticles are easily introduced in to cancer cells, which is why the nanoparticles synthesized by this method for experiments involving the interaction of gold nanoparticles with DNA of the calf thymus gland DNA (CT-DNA) using UV-Vis spectroscopy technique in trace buffer containing chloride Sodium (10 mM) and pH = 7 at 300 K were studied. The cytotoxicity studies of gold nanoparticles by MTT on the breast cancer cell line (MCF-7) showed Ic50 of gold nanoparticles of 24.1. Therefore, these nanoparticles are capable of inhibiting the activity, growth and proliferation of cancerous cells at low concentrations
Keywords
Nano
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  • Receive Date 14 August 2021
  • Revise Date 01 September 2021
  • Accept Date 05 September 2021