Nanomeghyas

Nanomeghyas

Analysis of Superparamagnetic Nanoparticles Fe3O4 in Alternating Magnetic Field with Different Sizes on A-549 Human Lung Cancer Cell Line

Document Type : Original Article

Abstract
Magnetic fluid hyperthermia is a new subclass of cancer treatment in which super-paramagnetic nanoparticles injected or diffused in cancerous tissue while exposing alternating magnetic field. The aim of this study is to scrutinize the effects of nanoparticles’concentration, resonance frequency, the coil’s resonance frequency and time as well as the magnetic field intensity on A-549 human lung cancer line.In this study, after culturing A-549 human lung cancer line, the four different nanoparticles’ diameters at three different frequencies, three different magnetic field intensities and four concentrations of nanoparticles were arranged to study the importance of them whilst a series of the three coils was designed to produce magneticHaving weighed the importance of parameters including the resonance coil’s frequency, nanoparticles’ resonance frequency and sizes, nanoparticles concentrations, the magnetic field intensity and iron uptake of cell line, we are inclined to believe that these parameters play a pivotal role in the hyperthermic temperature difference whilst this temperature difference equal to 5±0.5 0C can able to kill al cancerous A-549 cells.

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  • Receive Date 18 December 2020
  • Revise Date 02 July 2021
  • Accept Date 03 July 2021