Nanomeghyas

Nanomeghyas

Investigation on the physico-chemical and anticancer properties of nano oxalli-palladium using aqueous extract of silybum marianum

Document Type : Original Article

Authors
adeleh divsalar
Fahimeh Azadimanesh 1
Ali Akbar Saboury 2
1 1Department of Biology Science and Research branch, Islamic Azad University
2 Institute of Biochemistry and Biophysics, University of Tehran
Abstract
Cancer is one of the most important health problems throughout the world. Despite of improvement and enormous research in the areas of biomedical, cancer is still one of the main causes of death. So, the development of advanced techniques is one of the necessary subjects in cancer treatment. Development of cost-effective and accommodated synthetic methods is considered as a one of the important aspects of nanotechnology for producing metal nanoparticles with unique properties. The aim of this study is production of the oxali-palladium nanoparticles using the aqueous extract of plant seeds of silybum marianum.
The reduction of palladium ions was determined after incubation and reaction of plant extract with the solution of oxali –palladium at temperatures of 50 ºC. Also the physico-chemical properties of the synthesized oxali-palladium nanoparticles via green chemistry method were examined using UV-Visible spectroscopy, dynamic light scattering (DLS) and Scanning Electron Microscopy (SEM). Finally, the cytotoxicity and anti-proliferative properties of a new designed nanoparticle against human colon cancer cell line of HCT116 was evaluated.
Result of UV-Visible spectroscopy and DLS were indicated the formation of stable oxali-palladium nanoparticles at 50ºC with dimension of 60 nanometer. Also based on the results of SEM, the oxali-palladium nanoparticles have a homogenous morphology. Results of the cytotoxicity show that the oxali-palladium nanoparticles produced a dose and time – response suppression on growing of HCT116 cell lines.
Synthesis of oxali-palladium nanoparticles using green chemistry technique by aqueous extract of plant seeds of silybum marianum is a sustainable and cost-effective way to produce nanoparticles with specific properties in cancer treatment.
Keywords
Oxalli-palladium
green chemistry
silybum marianum extract
anticancer
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  • Receive Date 01 April 2019
  • Revise Date 23 March 0621
  • Accept Date 04 January 2021