Ultra-Sensitive, Rapid Gold Nano Rod-Quantum
Dot (RQ) Plexcitonic Self-Assembled
Aptamer-based Nanobiosensor for the
Detection of Human Cardiac Troponin I
Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Abstract
Acute Myocardial Infarction AMI is one of the leading causes of death throughout the world. Usual methods for detecting AMI are expensive, time-consuming and using blood samples as biological samples. Therefore, creating an ultra-fast, sensitive and non-invasive diagnostic test is necessary. Herein, a novel ultra-sensitive, fluorescent, plasmon-exciton coupling hybrid of a Gold Nano Rod-Quantum Dot RQ -based aptamer nanobiosensor is presented for the detection of human cardiac troponin I cTnI, the golden biomarker of AMI, and a preclinical test is performed with saliva. The binding of the cTnI protein to aptamer leads to a fluorescence enhancement of the plexcitonic hybrid system. The limit of detection of this nanobiosensor is 0.5 fM. It seems this novel nanobiosensor of the RQ plexcitonic hybrid system can open up new opportunities for the design and fabrication of nanobiosensor progress in nanobiotechnology.
Rezaei,Z. and Ranjbar,B. (2015). Ultra-Sensitive, Rapid Gold Nano Rod-Quantum
Dot (RQ) Plexcitonic Self-Assembled
Aptamer-based Nanobiosensor for the
Detection of Human Cardiac Troponin I. (e46701). Nanomeghyas, 2(3), e46701
MLA
Rezaei,Z. , and Ranjbar,B. . "Ultra-Sensitive, Rapid Gold Nano Rod-Quantum
Dot (RQ) Plexcitonic Self-Assembled
Aptamer-based Nanobiosensor for the
Detection of Human Cardiac Troponin I" .e46701 , Nanomeghyas, 2, 3, 2015, e46701.
HARVARD
Rezaei Z., Ranjbar B. (2015). 'Ultra-Sensitive, Rapid Gold Nano Rod-Quantum
Dot (RQ) Plexcitonic Self-Assembled
Aptamer-based Nanobiosensor for the
Detection of Human Cardiac Troponin I', Nanomeghyas, 2(3), e46701.
CHICAGO
Z. Rezaei and B. Ranjbar, "Ultra-Sensitive, Rapid Gold Nano Rod-Quantum
Dot (RQ) Plexcitonic Self-Assembled
Aptamer-based Nanobiosensor for the
Detection of Human Cardiac Troponin I," Nanomeghyas, 2 3 (2015): e46701,
VANCOUVER
Rezaei Z., Ranjbar B. Ultra-Sensitive, Rapid Gold Nano Rod-Quantum
Dot (RQ) Plexcitonic Self-Assembled
Aptamer-based Nanobiosensor for the
Detection of Human Cardiac Troponin I. Nanomeghyas, 2015; 2(3): e46701.
