Application of atomic force microscopy in critical force and critical time extraction of 2D manipulation for gastric cancer tissue with different friction models

Document Type : Original Article

Author

Department of Mechanical Engineering, Arak University, Arak, Iran

Abstract

Abstract: In order to better understand and improve the treatment of cancer, the study of the structural properties and mechanical properties of healthy cell tissues is of great importance. Therefore, the process of Nano manipulation of cancerous and healthy tissues using atomic force microscopy leads to the recognition of this disease. In this study, the critical force and time of gastric cancer tissue in the manipulation process have been evaluated by considering frictional forces with different models. In the general process of manipulation, a critical force occurs when overcoming resistive forces such as friction, and the high force causes damage to cancerous tissues. Coulomb, LuGre and HK friction models have been used in this research. By analyzing the topographic images obtained by atomic force microscopy, the geometry of gastric cancer tissue is assumed to be spherical. The simulations are performed by different friction models. Graphs of all forces are plotted in 2D manipulation, and the resultant force diagram is used for comparison. After fixing the amount of force in different friction models, the amount of force and critical time are considered. The lowest force and critical time for gastric cancer tissue were also recorded for the LuGre friction model with 0.51 nN and 64 ms.

Keywords

References

[1] F. J. Rubio-Sierra, W. M. Heckl, and R. W. Stark, “Nanomanipulation by atomic force microscopy”, Advanced Engineering Materials, 7(4), 193-196, 2005.
[2] S. Floyd, Ch. Pawashe, and M. Sitti, “Two-dimensional contact and noncontact micromanipulation in liquid using an untethered mobile magnetic microrobot”, IEEE Transactions on Robotics, 25(6), 1332-1342, 2009.
[3] B. Zarei, S. Bathaee, M. Taheri, and M. Momeni, “Second phase of nanomanipulation of particles by atomic force microscopy using Coulomb, HK, and LuGre Friction Models”, Modares Mechanical Engineering, 19(1), 181-190, 2019.
[4] M. H. Korayem, M. Taheri, and M. Zakeri, “Sensitivity Analysis of Nanoparticles Manipulation Based on Different Friction Models”, Applied Surface Science, 258(18), 6713-6722, 2012.
[5] M. Zakeri, M. Kharazmi, “Modeling of Friction in Micro/Nano scale with Random Roughness Distribution”, Modares Mechanical Engineering, 14(11), 2015.
[6] M. Zakeri, J. Faraji, M. Kharazmi, “Multipoint contact modeling of nanoparticle manipulation on rough surface”, Journal of Nanoparticle Research, 18 (374), 1-23, 2016.
[7] M. H. Korayem, M. Taheri, and Z. Rastegar, “Sobol Method Application in Sensitivity Analysis of LuGre Friction Model‎ During 2D Manipulation‎”, Scientia Iranica, 21(4), 1461-1469, 2014.
[8] S. Z. Mohammadi, M. Moghadam, and H. N. Pishkenari, “Dynamical modeling of manipulation process in Trolling-Mode AFM”, Ultramicroscopy, 197, 83-94, 2019.
[9] M. Taheri, “Sensitivity analysis of 3D manipulation of spherical nanoparticles by using E-fast method”, Modares Mechanical Engineering, 17(11), 59-69, 2018.
[10] M. Taheri, “3D-Dynamic modeling and simulation of biological nanoparticle motion using AFM nano–robot”, Modares Mechanical Engineering, 15(12). 311-316, 2016.
[11] A. H. Korayem, M. Taheri, and M. H. Korayem, “Dynamic Modeling and simulation of nano particle motion in different environments using AFM nano–robot”, Modares Mechanical Engineering, 15(1), 294-300, 2015.
[12] S. Yuan, L. Liu, Z. Wang, N. Xi, and Y. Wang, “Study of nano-manipulation approach based on the least action principle using AFM based robotic system”, in:  2017 36th Chinese Control Conference (CCC), IEEE,  4424-4429, 2017.
[13] M. H. Korayem, M. Estaji, and A. Homayooni, “Molecular dynamic modeling of bioparticles nanomanipulation based on AFM: investigating substrate effects”, Modares Mechanical Engineering, 17(3), 437-445, 2017.
[14] M. Taheri, “Determination of the young modulus of gastric cancer tissue experimentally using atomic force microscopy”, Modares Mechanical Engineering, 20(12), 2709-2720, 2020.
[15] Y. Zhang, J. Zhao, H. Yu, P. Li, W. Liang, Z. Liu, G.B. Lee, L. Liu, W.J. Li, and Z. Wang, “Detection and isolation of free cancer cells from ascites and peritoneal lavages using optically induced electrokinetics (OEK)”, Science advances, 6(32), eaba9628, 2020.
[16] Y. Saijo, M. Tanaka, H. Okawai, and F. Dunn, “The ultrasonic properties of gastric cancer tissues obtained with a scanning acoustic microscope system”, Ultrasound in medicine & biology, 17(7), 709-714, 1991.
[17] M. H. Korayem, K. Heidary, and Z. Rastegar, “The head and neck cancer (HN-5) cell line properties extraction by AFM”, Journal of biological engineering, 14(1), 1-15, 2020.
[18] E. A. Corbin, F. Kong, C. T. Lim, W. P. King, and R. Bashir, “Biophysical properties of human breast cancer cells measured using silicon MEMS resonators and atomic force microscopy”, Lab on a Chip, 15(3), 839-847, 2015.
[19] E. C. Faria, N. Ma, E. Gazi, P. Gardner, M. Brown, N. W. Clarke, and R. D. Snook, “Measurement of elastic properties of prostate cancer cells using AFM”, Analyst, 133(11), 1498-1500, 2008.
[20] C. D. Wit, H. Olsson, K. J. Astrom, and P. Lischinsky, “A New Model for Control of Systems with Friction”, IEEE Transactions on Automatic Control, 40, 419-425, 1995.
[21] J. A. Hurtado, and K. S. Kim, “Scale Effects in Friction of Single Asperity Contacts: Part 2; Multiple-Dislocation-Cooperated Slip”, Proceedings of the Royal Society of London Series A, A455, 3385–3400, 1999.
 
 

Files

History

  • Receive Date: 18 August 2021
  • Revise Date: 29 December 2021
  • Accept Date: 30 January 2022

Share

How to cite

Statistics