نانومقیاس

نانومقیاس

ساخت و آنالیز فیزیکوشیمیایی نانوفیبرهای حاوی آزلائیک اسید و ارزیابی زیست سازگاری پوستی آن

نوع مقاله : مقاله پژوهشی

نویسندگان
مرکز تحقیقات دارورسانی نانو، پژوهشکده فناوری سلامت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
چکیده
اختلال در فرآیند ترمیم زخم‌های پوستی، به‌ویژه در شرایطی نظیر وسعت بالای زخم، عفونت و بازسازی ناکارآمد بافت، می‌تواند منجر به ایجاد زخم‌های مزمن و خطرات تهدید کننده سلامت شود. در سال‌های اخیر، استفاده از پوشش‌های نانوفیبری بدلیل ویژگی های منحصر به فرد به‌عنوان رویکردی نوین برای ارتقای کارایی درمان و کاهش عوارض جانبی دارویی مورد توجه قرار گرفته است. در این مطالعه، نانوالیاف پلی‌وینیل‌الکل/کیتوزان حاوی آزلائیک اسید با هدف کاربرد در پوشش زخم پوستی طراحی و تهیه شد. نانوالیاف به روش الکتروریسی ساخته شده و ویژگی‌های فیزیکوشیمیایی، پروفایل رهایش دارو، تخریب‌پذیری، خون‌سازگاری و زیست‌پذیری سلولی آن‌ها مورد ارزیابی قرار گرفت. نتایج نشان داد بارگذاری آزلائیک اسید تا 2۰ درصد وزنی منجر به تشکیل نانوالیافی یکنواخت، پیوسته و بدون نقص با قطر نانومتری شد. آنالیز ماون قرمز برهم‌کنش‌های ساختاری مناسب میان آزلائیک اسید و ماتریس پلیمری را تأیید کرد. پوشش نانوفیبری تهیه‌شده دارای سطح آبدوست، تخلخل بالا، جذب مایعات مناسب و استحکام مکانیکی مطلوب برای کاربردهای پوشش زخم بود. علاوه بر این، رهایش کنترل‌شده دارو طی ۷۲ ساعت، تخریب‌پذیری تدریجی، خون‌سازگاری مطلوب و بهبود معنادار حیات سلولی فیبروبلاست‌ها مشاهده شد. در مجموع، نانوالیاف پلی‌وینیل‌الکل/کیتوزان حاوی آزلائیک اسید به‌عنوان یک پوشش زخم چندمنظوره، پتانسیل قابل‌توجهی برای تسریع ترمیم زخم‌های پوستی دارد.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Fabrication and physicochemical characterization of azelaic acid-loaded nanofibers and evaluation of their skin biocompatibility

نویسندگان English

Hassan Maleki
Navid Zarei
Maryam Doostan
Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده English

Impairment of the cutaneous wound healing process, particularly under conditions such as large wound size, infection, and inefficient tissue regeneration, can lead to the development of chronic wounds and pose serious health-threatening risks. In recent years, nanofibrous wound dressings with unique properties have attracted considerable attention as a novel strategy to enhance therapeutic efficacy while minimizing drug-related side effects. In the present study, poly(vinyl alcohol)/chitosan nanofibers loaded with azelaic acid were designed and fabricated for skin wound dressing applications. The nanofibers were produced via electrospinning, and their physicochemical properties, drug-release profile, degradation behavior, hemocompatibility, and cellular biocompatibility were systematically evaluated. The results demonstrated that azelaic acid loading up to 20 wt% led to the formation of uniform, and defect-free nanofibers with nanoscale diameters. The analysis confirmed favorable structural interactions between azelaic acid and the polymeric matrix. The prepared nanofibrous dressing exhibited a highly hydrophilic surface, high porosity, adequate fluid absorption capacity, and suitable mechanical strength for wound dressing applications. Furthermore, sustained drug release over 72 h, gradual degradation, excellent hemocompatibility, and a significant enhancement in fibroblast cell viability were observed. Overall, azelaic acid–loaded poly(vinyl alcohol)/chitosan nanofibers demonstrate considerable potential as a multifunctional wound dressing for accelerating cutaneous wound healing.

کلیدواژه‌ها English

Azelaic Acid
Biocompatibility
Electrospinning
Nanofiber
Wound Dressing
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دوره 12، شماره 4
زمستان 1404
صفحه 422-439

  • تاریخ دریافت 14 آذر 1404
  • تاریخ بازنگری 10 دی 1404
  • تاریخ پذیرش 25 اسفند 1404