ساخت و ارزیابی نانوذرات زئولیت ZSM-5 اصلاح شده با بتاسیکلودکسترین به عنوان حامل برای کورکومین

نویسندگان

1 گروه شیمی، دانشکده علوم پایه، دانشگاه بینالمللی امام خمینی)ره(، قزوین

2 گروه شیمی، دانشکده علوم پایه، دانشگاه بینالمللی امام خمینی (ره)، قزوین

3 دانشگاه بین‌المللی امام خمینی ره - گروه شیمی

چکیده

در این پژوهش، نانو زئولیت ZSM-5بدون قالب به روش هیدروترمال سنتز و با بتاسیکلودکسترین اصلاح شد. در مرحله بعد برای بارگذاری کورکومین در نانو حامل از روش رفلاکس متانول استفاده شد تا پایداری بیشتری برای حمل دارو داشته باشد. تعیین خصوصیات نانوذرات تهیه شده توسط پراش پرتوX، میکروسکوپ الکترونی روبشی، طیف سنج زیر قرمز تبدیل فوریه، طیف بینی پراکنش انرژی پرتو ایکس و آنالیز وزن سنجی حرارتی انجام شد. بازده بارگذاری و رهایش دارو با استفاده از روش اسپکتروفتومتری UV-Vis بررسی شد. تصاویر میکروسکوپ الکترونی روبشی نشان داد که اندازه ذرات زئولیتZSM-5حدود 44 نانومتر است و طیف سنج زیر قرمز تبدیل فوریه، طیف بینی پراکنش انرژی پرتو ایکس و نیز آنالیز وزن سنجی حرارتی، سنتز و عامل دارشدن نانو ذرات زئولیت با سیکلودکسترین و همچنین تشکیل کمپلکس نانوزئولیت اصلاح شده و کورکومین را تایید کرد.بازده بارگذاری دارو بر سطح نانوذرات در شرایط بهینه 95 بود و بازده رهایش دارو در 4/7 pH حدود 43 درصد و در 5/5 pHحدود 61 درصد ارزیابی شد که بیانگر کارایی بالای سیستم حامل دارو در بافت‌های سرطانی در مقایسه با بافت‌های سالم است. بنابراین نانو حامل سنتز شده رویکرد بسیار مناسبی برای تحویل دارو‌های آب‌گریز مانند کورکومین به بافت هدف است که کاربردشان در درمان به دلیل فعالیت دارویی نامطلوب وفراهمی زیستی پایین محدود شده است

کلیدواژه‌ها


عنوان مقاله [English]

Fabrication and Evaluation of β-Cyclodextrin Modified Nano Zeolite as Carrier for Curcumin

نویسندگان [English]

  • N. Rahmani 1
  • A. Bagheri Garmarudi 2
  • M Khanmohammadi 3
1
2
3
چکیده [English]

In this study, nano ZSM-5 zeolite was synthesized in the absence of organic template by hydrothermal method. In the next step for loading of curcumin in nano carrier was selected methanol reflux method. Characterization of nanoparticles was performed by X-ray diffraction, Scanning electron microscope, Fourier transform infrared spectroscopy and Thermal gravimetric analysis. Efficiency of loading and drug release was determined by UV-Vis spectrophotometry. Scanning electron microscopy showed that smallest of particle size is approximately 44 nm. Fourier transform infrared spectrometer and Thermal gravimetric analysis confirmed synthesis and functionalization of nano zeolite with cyclodextrin as well as complex formation of curcumin and modified nano zeolite. The drug loading on the surface of the nanoparticles in optimal conditions was 95. and efficiency of drug release was evaluated 43 in pH 7.4 and 61 in pH5.5. This indicates that the performance of the drug delivery system in tumor tissues is higher than healthy tissues. The synthesized nanocarrier is an appropriate approach for the delivery of hydrophobic drugs to the target tissue such as curcumin drug that has sub-optimal pharmacokinetics and poor bioavailability.

کلیدواژه‌ها [English]

  • Zeolite
  • Cyclodextrin
  • Drug delivery
  • Curcumin
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