فهرست

استخراج آتراکریوم بسیلات در نمونه¬های حقیقی با استفاده از استخراج فاز جامد مخلوط مایسلی

نشریه: تابستان ۱۳۹۶ - مقاله 2   صفحات :  109 تا 119



کد مقاله:
nm-245

مولفین:
اسلام پوربشیر: دانشگاه پیام نور تهران - دانشکده شیمی
سارا مالی: پیام نور - شیمی
ژیلا آذری: پیام نور - شیمی


چکیده مقاله:

استخراج فاز جامد مغناطیسی، به عنوان روشی ساده، سریع و حساس، برای استخراج و اندازه¬گیری داروی آتراکریوم بسیلات در نمونه های آب، ادرار و پلاسما با اسپکتروسکوپی فرابنفش-مرئی انجام شد. نانو ذرات اکسیدآهن اصلاح شده با سدیم دودسیل سولفات به عنوان جاذب استفاده شد. پارامتر های موثر بر استخراج داروی آتراکریوم بسیلات نظیرpH ، مقدار جاذب و ماده فعال سطحی، زمان استخراج و شرایط واجذب مورد مطالعه واقع شد. تحت شرایط بهینه شده، دارو به میزان 5/99 ، 96 و 5/98 درصد در آب، ادرار و پلاسما به ترتیب استخراج شد. حدتشخیص روش به میزان 77/4، 55/6 و 34/4 میکروگرم بر میلی لیتر به ترتیب در نمونه های آب، ادرار و پلاسما بدست آمد. تمامی فرآیند استخراج، سرعت کافی، کارآمد بودن و داشتن صرفه اقتصادی استخراج آتراکریوم بسیلات در نمونه های حقیقی را تصدیق کرد.


Article's English abstract:

A simple, rapid and sensitive method termed as magnetic solid phase extraction MSPE combined with uv-vis spectrophotometry has been proposed for the extraction and determination of atracurium besilat ATB in water, urine and plasma samples. The sodium dodecyl sulfate SDS coated Fe3O4 nanoparticles NPs has been used as a sorbent. Several factors influencing the extraction efficiency of ATB, such as pH, surfactant and adsorbent amounts, extraction time and desorption conditions, were studied. Under the optimal conditions, the extraction percentage of ATB was 98.5, 96 and 99.5 in water, urine and plasma samples, respectively. The limits of detections LODs of the proposed approach were 4.77, 6.55 and 4.34 µg/mL in water, urine and plasma samples, respectively. The whole operation showed to be enough fast, useful and economical for extraction of Atracurium besilat from real samples.


کلید واژگان:
آتراکریوم بسیلات، اسپکتروسکوپی، استخراج فاز جامد مغناطیسی، نانو ذرات آهن

English Keywords:
Magnetic solid phase extraction; Fe3O4 nanoparticles; Atracurium besilat; Spectrophotometry

منابع:
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English References:
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